![]() Therapy with PROZAC may be resumed 24 hours after the last dose of linezolid or intravenous methylene blue. The patient should be monitored for symptoms of serotonin syndrome for five weeks or until 24 hours after the last dose of linezolid or intravenous methylene blue, whichever comes first. If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, PROZAC should be stopped promptly, and linezolid or intravenous methylene blue can be administered. In some cases, a patient already receiving PROZAC therapy may require urgent treatment with linezolid or intravenous methylene blue. In a patient who requires more urgent treatment of a psychiatric condition, other interventions, including hospitalization, should be considered. Use of PROZAC with Other MAOIs such as Linezolid or Methylene Blueĭo not start PROZAC in a patient who is being treated with linezolid or intravenous methylene blue because there is an increased risk of serotonin syndrome. PROZAC monotherapy is not indicated for the treatment of treatment resistant depression (Major Depressive Disorder in patients who do not respond to 2 antidepressants of adequate dose and duration in the current episode). Safety of coadministration of doses above 18 mg olanzapine with 75 mg fluoxetine has not been evaluated in clinical studies. ![]() Periodically re-examine the need for continued pharmacotherapy. Adjust dosage, if indicated, with the individual components according to efficacy and tolerability. Table 1 demonstrates the appropriate individual component doses of PROZAC and olanzapine versus Symbyax. Symbyax is dosed between 3 mg/25 mg (olanzapine/fluoxetine) per day and 12 mg/50 mg (olanzapine/fluoxetine) per day. Safety and efficacy of fluoxetine in combination with olanzapine was determined in clinical trials supporting approval of Symbyax (fixed dose combination of olanzapine and fluoxetine). Antidepressant efficacy was demonstrated with olanzapine and fluoxetine in combination with a dose range of olanzapine 6 to 18 mg and fluoxetine 25 to 50 mg. ![]() Adjust dosage, if indicated, according to efficacy and tolerability within dose ranges of fluoxetine 20 to 50 mg and oral olanzapine 5 to 20 mg. PROZAC and Olanzapine in Combination: Treatment Resistant DepressionĪdminister fluoxetine in combination with oral olanzapine once daily in the evening, without regard to meals, generally beginning with 5 mg of oral olanzapine and 20 mg of fluoxetine. PROZAC monotherapy is not indicated for the treatment of depressive episodes associated with Bipolar I Disorder. Table 1: Approximate Dose Correspondence Between Symbyax 1 and the Combination of PROZAC and Olanzapineġ Symbyax (olanzapine/fluoxetine HCL) is a fixed-dose combination of PROZAC and olanzapine. The following table demonstrates the appropriate individual component doses of PROZAC and olanzapine versus Symbyax. Safety and efficacy of fluoxetine in combination with olanzapine was determined in clinical trials supporting approval of Symbyax (fixed-dose combination of olanzapine and fluoxetine). Safety of co-administration of doses above 12 mg of olanzapine with 50 mg of fluoxetine has not been evaluated in pediatric clinical studies. ![]() Make dosage adjustments, if indicated, according to efficacy and tolerability. Periodically re-examine the need for continued pharmacotherapy.Ĭhildren and adolescents (10 -17 years of age) - Administer olanzapine and fluoxetine combination once daily in the evening, generally beginning with 2.5 mg of olanzapine and 20 mg of fluoxetine. Safety of co-administration of doses above 18 mg olanzapine with 75 mg fluoxetine has not been evaluated in clinical studies. Antidepressant efficacy was demonstrated with olanzapine and fluoxetine in combination with a dose range of olanzapine 6 to 12 mg and fluoxetine 25 to 50 mg. Make dosage adjustments, if indicated, according to efficacy and tolerability within dose ranges of fluoxetine 20 to 50 mg and oral olanzapine 5 to 12.5 mg. When using PROZAC and olanzapine in combination, also refer to the Clinical Studies section of the package insert for Symbyax.Īdult - Administer fluoxetine in combination with oral olanzapine once daily in the evening, without regard to meals, generally beginning with 5 mg of oral olanzapine and 20 mg of fluoxetine. PROZAC and Olanzapine in Combination: Depressive Episodes Associated with Bipolar I Disorder
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